Oxysterol-binding protein (OSBP)-related proteins (ORPs) 5 and 8 have been shown to deplete the lipid phosphatidylinositol 4-phosphate (PI4P) at sites of membrane contact between the endoplasmic reticulum (ER) and plasma membrane (PM).This is believed to be caused by transport of PI4P from the PM to the ER, where PI4P is degraded by an ER-localized
Detector-size upper bounds on dark hadron lifetime from cosmology
Abstract We show that in a confining hidden valley model where the lightest hidden particles are dark hadrons that have mass splittings larger than O 0.1 $$ mathcal{O}(0.1) $$ GeV, if the lightest dark hadron is either stable or decays into Standard Model (SM) hadrons/charged leptons during the big-bang nucleosynthesis (BBN), at least one of the he
Constitutive modeling of the mechanical response of arterial tissues
Despite the tremendous impact that a good constitutive relation for the response of arterial tissues can have with regard to advances in cardiovascular science and medicine, and notwithstanding the intense effort to put a felicitous constitutive relation into place, no reliable constitutive relation is available in the literature.In this review art
Intracoronary pharmacological therapy versus aspiration thrombectomy in STEMI (IPAT-STEMI): A systematic review and meta-analysis of randomized trials.
BackgroundThrombus load in STEMI patients remains a challenge in practice.It aggravates coronary obstruction leading to impaired myocardial perfusion, worsened cardiac function, and adverse clinical outcomes.Various strategies have been advocated to reduce thrombus burden.ObjectivesThis meta-analysis aimed to evaluate the effectiveness of intracoro